Insights into Molecular Mechanisms: NUPR1-CHOP Interplay, Autophagosome Formation, and Cell Death in Chronic Methamphetamine Use

Abstract

This study explores the molecular intricacies of chronic methamphetamine (METH) use, particularly focusing on the interplay between NUPR1-CHOP expression, autophagosome formation, and cell death in the striatum. These findings provide crucial insights into the underlying molecular mechanisms driving METH-induced neurotoxicity, underscoring the pivotal role of the NUPR1-CHOP pathway. Understanding these mechanisms holds promise for developing targeted therapeutic interventions to mitigate the adverse neurological effects of chronic METH abuse, ultimately improving outcomes for affected individuals. Understanding the molecular interplay between NUPR1-CHOP, autophagy, and cell death pathways in chronic METH use is crucial for developing targeted therapeutic interventions to mitigate its adverse neurological effects. Ultimately, this research contributes to advancing our understanding of the molecular underpinnings of chronic METH abuse and offers promise for improving outcomes for affected individuals through targeted therapeutic strategies.